Transfusion Reactions

Number of Credits

1.5 P.A.C.E.®




Course Details:

This course is a review of clinical and laboratory recognition of transfusion reactions and the responsibilities of both areas for prevention of and proper response to a suspected reaction. 

Intended Audience: This program is designed as an educational and training tool for Clinical laboratory scientists, technologists and technicians. This course is also appropriate for clinical laboratory science students and pathology residents.

Learning Objectives

  • Define transfusion reaction.
  • Identify the risks of transfusions.
  • Compare and contrast immediate hemolytic transfusion reactions and delayed hemolytic transfusion reactions.
  • List and define the types of nonhemolytic transfusion reactions.
  • List the laboratory findings associated with hemolytic and nonhemolytic transfusion reactions.
  • Discuss the definition, pathophysiology, signs, symptoms, therapies, prevention, and clinical work-up of hemolytic and nonhemolytic transfusion reactions.
  • List the antibodies associated with hemolytic transfusion reactions.
  • List the steps and procedures to follow in a laboratory investigation of a transfusion reaction.

This course has been approved for P.A.C.E.® credit. There are no prerequisites for this course.

Adverse Effects of Blood Transfusions

Blood Component Transfusion Risks

Acute Immunologic Transfusion Reactions

  • Acute Hemolytic Transfusion Reactions
  • Febrile Nonhemolytic Transfusion Reactions
  • Allergic Transfusion Reaction
  • Transfusion-Related Acute Lung Injury (TRALI)

Delayed Immunologic Transfusion Reactions

  • Delayed Hemolytic Transfusion Reactions
  • Transfusion-Associated Graft Versus Host Disease (TA-GVHD)
  • Post-Transfusion Purpura (PTP)

Acute Nonimmunologic Transfusion Reactions

  • Bacterial Contamination
  • Circulatory Overload
  • Physical/Chemical Hemolysis

Delayed NonImmunologic Transfusion Reactions

Role of Medical Personnel Performing the Transfusion

Laboratory Investigation of a Transfusion Reaction.

Reporting Transfusion Reactions


Graded Exam

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